Methylprednisolone acetate

From Cat

Methylprednisolone acetate is commonly available as Depomedrol, a depot prednisolone drug which acts as a slow release corticosteroid for use in cats.

Methylprednisolone acetate is used extensively in feline medicine for long-term management of irritable bowel disease, atopy, eosinophilic granuloma complex and overgrooming[1].

It is contraindicated in cats with diabetes mellitus, congestive heart failure[2], chronic renal disease and Cushing's syndrome[3].

It is sometimes used in salvage cases, e.g palliative care in cats with chronic squamous cell carcinoma, and as an adjunct in chemotherapy[4].

Side effects are common, especially biochemical changes to albumin, lipase and electrolytes, as well as dermatological changes such as localized injection-site alopecia and mild generalized exfoliative dandruff[5].

Dose rate: 10 - 20 mg/cat SQ once monthly or every 2 - 3 months as required.


  1. Waisglass SE et al (2006) Underlying medical conditions in cats with presumptive psychogenic alopecia. J Am Vet Med Assoc 228(11):1705-1709
  2. Ployngam T et al (2006) Hemodynamic effects of methylprednisolone acetate administration in cats. Am J Vet Res 67(4):583-587
  3. Albanese F, et al (2009) Feline perforating dermatitis resembling human reactive perforating collagenosis: clinicopathological findings and outcome in four cases. Vet Dermatol 20(4):273-80
  4. Wright ZM, & Chretin JD (2006) Diagnosis and treatment of a feline oral mast cell tumor. J Feline Med Surg 8(4):285-289
  5. Sharkey LC et al (2007) Effects of a single injection of methylprednisolone acetate on serum biochemical parameters in 11 cats. Vet Clin Pathol 36(2):184-187