From Cow
Congenital micropthalmos and microcornea in a cow

Microphthalmos is a rare autosomal recessive congenital eye disease of calves worldwide[1].

This disease is characterised by a calf born with a small or absent eye[2]. In White Shorthorn cattle hereditary microphthalmos is associated with large lids and third eyelid, resulting in entropion.

In cattle, microphthalmos is often associated with other diseases such as anasarca and bovine viral diarrhea.

Other congenital diseases such as microcornea, microcoria, heterochromia iridis, microlentia, cataracts, retinal dysplasia, retinal detachment, anterior segment dysgenesis, acorea and proliferation of the anterior neuroectoderm[3].

Affected calves are usually culled or the diseased eye removed.


  1. Abbasi AR et al (2009) A mutation of the WFDC1 gene is responsible for multiple ocular defects in cattle. Genomics 94(1):55-62
  2. Kaswan RL et al (1987) Multiple hereditary ocular anomalies in a herd of cattle. J Am Vet Med Assoc 191(1):97-99
  3. Rupp GP & Knight AP (1984) Congenital ocular defects in a crossbred beef herd. J Am Vet Med Assoc 184(9):1149-1150