Sterile nodular panniculitis
The disease is characterized by fever and multiple subcutaneous nodules, but in more rare cases systemic signs have been observed such as sterile neutrophilic-macrophagic lymphadenitis with vasculitis associated with gastrointestinal and pulmonary signs.
Pansteatitis is commonly associated with this disease, presenting as inflammation of subcutaneous, mesenteric and falciform fat.
Microbiological examination of tissues is usually negative.
Diagnosis is based on histological analysis of biopsied tissue samples. A definitive diagnosis requires multiple skin biopsies.
Other ancillary tests may be indicated, such as measurement of serum alpha1 antitrypsin, which can help establish an association with serum alpha-1 antitrypsin deficiency.
Treatment involves use of immunosuppressive drugs such as prednisolone or cyclosporine.
- DeManuelle TC & Stannard AA (1998) Difficult dermatologic diagnosis. Sterile nodular panniculitis. J Am Vet Med Assoc 213(3):356-357
- German AJ et al (2003) Sterile nodular panniculitis and pansteatitis in three weimaraners. J Small Anim Pract 44(10):449-455
- Dandrieux JR et al (2011) Unusual systemic signs in a dog with sterile neutrophilic-macrophagic lymphadenitis and nodular panniculitis. J Am Anim Hosp Assoc 47(2):117-121
- Moreau PM (1982) Disseminated necrotizing panniculitis and pancreatic nodular hyperplasia in a dog. J Am Vet Med Assoc 180(4):422-425
- Torres SM (1999) Sterile nodular dermatitis in dogs. Vet Clin North Am Small Anim Pract 29(6):1311-1323