Laboratory values

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Lymphocytes comprise 45–80% of the WBC count and small lymphocytes are similar in size to erythrocytes.

Large lymphocytes contain Kurloff bodies, large intracytoplasmic mucopolysaccharide inclusion bodies. Kurloff bodies occur under normal conditions in guinea pigs and are estrogen dependent.

Pregnant females may have 2–5% lymphocytes with Kurloff bodies in their peripheral blood; they are present in large numbers in adult females and numbers fluctuate with the stage of estrous cycle. There are few Kurloff bodies in adult males, and they are rarely seen in newborns.

Normal vitals in guinea pigs

T (0C) 37.2 - 39.5
HR 230 - 380 bpm
RR 42 - 104 bpm
Blood volume 6% of body weight
Life expectancy up to 8 years
Food intake 6 grams / 100 g body weight
Water intake 85 mL/day
First eat solid food 2 - 4 days old
Sexual maturity 4 - 6 weeks (♀ and ♂)
Estrus cycle 15 - 17 days
Ovulation Spontaneous, 10 hrs post-onset of estrus
Gestation 59 - 72 days
Litter size 1 - 6
Birth weight 75 - 10 grams

Normal guinea pig haematology & biochemistry

Parameter Normal Parameter Normal
Haemoglobin 11 - 15 g/L Calcium 5.3 - 12.0 mmol/L
Haematocrit (PCV) 37 - 48 % Phosphorus 3.0 - 7.6 mmol/L
Erythrocytes 4.5 - 7.0 x1012/L Magnesium 0.79 - 1.19 mmol/L
MCV 37.8 - 56.0 fL Sodium 135 - 145 mmol/L
MCH 14.2 - 20.1 pg Potassium 3.6 - 5.1 mmol/L
MCHC 317 - 404 g/L Chloride 96 - 105 mmol/L
Platelets 250 - 850 x109/L BUN 9.0 - 31.5 mmol/L
Leukocytes 7.0 - 18.0 x109/L Creatinine 60 - 220 µmol/L
Segmented Neutrophils 0.7 - 4.9 x109/L (15-61%) Glucose 2.5 - 3.8 mmol/L
Band Neutrophils 0.0 - 0.2 x109/L (0-2%) Cholesterol 2.0 - 6.2 mmol/L
Lymphocytes 1.0 - 5.8 x109/L (26-68%) Bilirubin 0 - 8.6 µmol/L
Monocytes 0.0 - 0.9 x109/L (0-12%) AST 24 - 45 IU/L
Eosinophils 0 - 1.9 x109/L (0-28%) ALT 5 - 18 IU/L
Basophils 0 - 0.1 x109/L (0-1%) Alkaline Phosphatase 3 - 46 IU/L